ClinicalTrials.gov
ClinicalTrials.gov is the official US registry of clinical research studies, run by the National Library of Medicine at the National Institutes of Health. Each record describes a study in a consistent structure: the condition being studied, the intervention being tested, eligibility criteria, locations, sponsors, and, where available, reported results.
Because the data is structured and openly licensed, it is well suited to RAG systems that answer questions about treatments, ongoing research, or trial design. You can search and pull records through the public API, or download bulk data for offline processing.
As a US Government work, the content is in the public domain, so you can reuse it freely. Registration of trials is required by law in many cases, which means the database stays current and broad in coverage.
Related sources
DrugBank
A freely accessible database that combines detailed drug data with drug target information, covering more than 15,000 drug entries. It links chemistry, pharmacology, and biology in one place, which makes it a strong knowledge source for medical and pharmaceutical RAG.
MIMIC-III / MIMIC-IV
Freely accessible critical care databases with de-identified health data from more than 40,000 intensive care patients at Beth Israel Deaconess Medical Center. They include vital signs, lab results, medications, and clinical notes. Access needs credentialing and a data-use agreement.
PhysioNet
A repository of freely available medical research data, including physiological signals such as ECG and EEG, clinical databases, and related software. It hosts MIMIC and many other biomedical datasets, so it is a central hub for clinical RAG source material.
UniProt
A resource for protein sequence and functional information, with more than 250 million protein sequences and rich annotations. It is a core reference for bioinformatics, so it grounds life sciences RAG systems in reliable protein facts.