UniProt
UniProt (the Universal Protein Resource) catalogues proteins across all forms of life, pairing each sequence with detailed annotations: function, structure, associated diseases, involved pathways, and links to other databases. It is organised into a manually reviewed, expert-curated set and a much larger automatically annotated set, so you can choose the balance of accuracy and coverage you need.
For RAG in the life sciences, UniProt provides a trustworthy backbone of protein knowledge. You can search and retrieve entries through a well-documented API, query the data programmatically, or download bulk files in several formats for offline indexing.
The data is released under CC BY 4.0, so you are free to reuse it with attribution.
Related sources
ClinicalTrials.gov
A US National Institutes of Health database of privately and publicly funded clinical studies. It holds structured records on more than 450,000 studies, including protocols, conditions, interventions, outcomes, and results, all in the public domain.
DrugBank
A freely accessible database that combines detailed drug data with drug target information, covering more than 15,000 drug entries. It links chemistry, pharmacology, and biology in one place, which makes it a strong knowledge source for medical and pharmaceutical RAG.
MIMIC-III / MIMIC-IV
Freely accessible critical care databases with de-identified health data from more than 40,000 intensive care patients at Beth Israel Deaconess Medical Center. They include vital signs, lab results, medications, and clinical notes. Access needs credentialing and a data-use agreement.
PhysioNet
A repository of freely available medical research data, including physiological signals such as ECG and EEG, clinical databases, and related software. It hosts MIMIC and many other biomedical datasets, so it is a central hub for clinical RAG source material.